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Vaccine Detail

Influenza virus DNA vaccine pCMV/Hl encoding H1
Vaccine Information
  • Vaccine Name: Influenza virus DNA vaccine pCMV/Hl encoding H1
  • Target Pathogen: Influenza virus
  • Target Disease: Influenza (flu)
  • Vaccine Ontology ID: VO_0004292
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • HA gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pCMV expressed influenza virus hemagglutinin subtype 1 (H1) glycoproteins (Fynan et al., 1993).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid:
    • DNA vaccine plasmid name:
    • DNA vaccine plasmid VO ID: VO_0000215
  • Immunization Route: Gene gun epidermis delivery
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: In mice, 95% protection was achieved by two immunizations with beads loaded with as little as 0.4 micrograms of DNA (Fynan et al., 1993).
References
Fynan et al., 1993: Fynan EF, Webster RG, Fuller DH, Haynes JR, Santoro JC, Robinson HL. DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations. Proceedings of the National Academy of Sciences of the United States of America. 1993; 90(24); 11478-11482. [PubMed: 8265577].