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Vaccine Detail

Influenza virus DNA vaccine pIRES/HA/IL-2 expressing HA
Vaccine Information
  • Vaccine Name: Influenza virus DNA vaccine pIRES/HA/IL-2 expressing HA
  • Target Pathogen: Influenza virus
  • Target Disease: Influenza (flu)
  • Vaccine Ontology ID: VO_0004296
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • HA gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pIRES expressed surface proteins hemagglutinin (HA) (Henke et al., 2006).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid:
    • DNA vaccine plasmid name:
    • DNA vaccine plasmid VO ID: VO_0000262
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Two inoculations of pIRES/HA/IL-2 protected 83.33% of mice against lethal influenza challenge (Henke et al., 2006).
References
Henke et al., 2006: Henke A, Rohland N, Zell R, Wutzler P. Co-expression of interleukin-2 by a bicistronic plasmid increases the efficacy of DNA immunization to prevent influenza virus infections. Intervirology. 2006; 49(4); 249-252. [PubMed: 16601357].