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Vaccine Detail

Influenza virus DNA vaccine pBK-SFV-HA
Vaccine Information
  • Vaccine Name: Influenza virus DNA vaccine pBK-SFV-HA
  • Target Pathogen: Influenza virus
  • Target Disease: Influenza (flu)
  • Vaccine Ontology ID: VO_0004304
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • HA gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pBK-SFV expressed surface proteins hemagglutinin (HA) (Berglund et al., 1998).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid:
    • DNA vaccine plasmid name:
    • DNA vaccine plasmid VO ID: VO_0000080
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Immunized animals acquired protective immunity to lethal influenza challenge. Five of seven immunized mice survived viral challenge, compared to one of four surviving mice in the saline-immunized control group (Berglund et al., 1998).
References
Berglund et al., 1998: Berglund P, Smerdou C, Fleeton MN, Tubulekas I, Liljeström P. Enhancing immune responses using suicidal DNA vaccines. Nature biotechnology. 1998; 16(6); 562-565. [PubMed: 9624688].