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Vaccine Detail
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Influenza virus DNA vaccine HA-DNA |
| Vaccine Information |
- Vaccine Name: Influenza virus DNA vaccine HA-DNA
- Target Pathogen: Influenza virus
- Target Disease: Influenza (flu)
- Vaccine Ontology ID: VO_0004305
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Macaque
- HA
gene engineering:
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000276
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0005006
- Immunization Route: Gene gun
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| Host Response |
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Human Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Vaccination was safe and well-tolerated and elicited protection from challenge in approximately 50% of subjects, providing the first proof-of-principle of a DNA vaccine affording protection in humans (Loudon et al., 2010).
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| References |
Loudon et al., 2010: Loudon PT, Yager EJ, Lynch DT, Narendran A, Stagnar C, Franchini AM, Fuller JT, White PA, Nyuandi J, Wiley CA, Murphey-Corb M, Fuller DH. GM-CSF increases mucosal and systemic immunogenicity of an H1N1 influenza DNA vaccine administered into the epidermis of non-human primates. PloS one. 2010; 5(6); e11021. [PubMed: 20544035].
Pertmer et al., 2001: Pertmer TM, Oran AE, Madorin CA, Robinson HL. Th1 genetic adjuvants modulate immune responses in neonates. Vaccine. 2001; 19(13-14); 1764-1771. [PubMed: 11166902].
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