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Vaccine Detail
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Influenza virus DNA vaccine NA-DNA |
| Vaccine Information |
- Vaccine Name: Influenza virus DNA vaccine NA-DNA
- Target Pathogen: Influenza virus
- Target Disease: Influenza (flu)
- Vaccine Ontology ID: VO_0004310
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- NA from A/Puerto Rico/8/1934(H1N1)
gene engineering:
- Type: DNA vaccine construction
- Description: Vector Pcaggsp7 expressed neuraminidase (NA) of A/PR/8/34 (PR8, H1N1) influenza virus (Chen et al., 1999).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0005000
- Immunization Route: Gene gun
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| Host Response |
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Mouse Response
- Vaccination Protocol: Mice were inoculated with each DNA construct twice, 3 weeks apart, at a dose of 1 microg per mouse by particle-mediated DNA transfer (gene gun) to the epidermis (Chen et al., 1999).
- Vaccine Immune Response Type: VO_0000286
- Challenge Protocol: They were challenged with a lethal dose of the homologous virus 7 days after the second vaccination (Chen et al., 1999).
- Efficacy: NA-DNA provided significant protection in all strains of mouse (Chen et al., 1999).
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| References |
Chen et al., 1999: Chen Z, Yoshikawa T, Kadowaki S, Hagiwara Y, Matsuo K, Asanuma H, Aizawa C, Kurata T, Tamura S. Protection and antibody responses in different strains of mouse immunized with plasmid DNAs encoding influenza virus haemagglutinin, neuraminidase and nucleoprotein. The Journal of general virology. 1999; 80 ( Pt 10); 2559-2564. [PubMed: 10573147].
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