|
|
Vaccine Detail
|
T. gondii DNA vaccine pcDNA3.1-SAG1-ROP2 |
| Vaccine Information |
- Vaccine Name: T. gondii DNA vaccine pcDNA3.1-SAG1-ROP2
- Target Pathogen: Toxoplasma gondii
- Target Disease: Toxoplasmosis
- Vaccine Ontology ID: VO_0004313
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- p30
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pcDNA3.1 expressed SAG1 (Xue et al., 2008).
- Detailed Gene Information: Click Here.
- Rop2
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pcDNA3.1 expressed ROP2 (Xue et al., 2008).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000158
- Immunization Route: Intramuscular injection (i.m.)
|
| Host Response |
|
Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: When challenged with Toxoplasma gondii RH strain, mice immunized with pIL-12 co-administration had significantly higher survival rates compared to co-administration with pCTA2/B or pcDNA3.1-SAG1-ROP2 alone (control) (Xue et al., 2008).
|
| References |
Xue et al., 2008: Xue M, He S, Zhang J, Cui Y, Yao Y, Wang H. Comparison of cholera toxin A2/B and murine interleukin-12 as adjuvants of Toxoplasma multi-antigenic SAG1-ROP2 DNA vaccine. Experimental parasitology. 2008; 119(3); 352-357. [PubMed: 18442818].
|
|
