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Vaccine Detail

T. gondii DNA vaccine pcDNA3.1-SAG1-ROP2
Vaccine Information
  • Vaccine Name: T. gondii DNA vaccine pcDNA3.1-SAG1-ROP2
  • Target Pathogen: Toxoplasma gondii
  • Target Disease: Toxoplasmosis
  • Vaccine Ontology ID: VO_0004313
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • p30 gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pcDNA3.1 expressed SAG1 (Xue et al., 2008).
    • Detailed Gene Information: Click Here.
  • Rop2 gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pcDNA3.1 expressed ROP2 (Xue et al., 2008).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pcDNA3.1 DNA vaccine plasmid
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: When challenged with Toxoplasma gondii RH strain, mice immunized with pIL-12 co-administration had significantly higher survival rates compared to co-administration with pCTA2/B or pcDNA3.1-SAG1-ROP2 alone (control) (Xue et al., 2008).
References
Xue et al., 2008: Xue M, He S, Zhang J, Cui Y, Yao Y, Wang H. Comparison of cholera toxin A2/B and murine interleukin-12 as adjuvants of Toxoplasma multi-antigenic SAG1-ROP2 DNA vaccine. Experimental parasitology. 2008; 119(3); 352-357. [PubMed: 18442818].