• Vaccine Name: Y. pestis DNA vaccine F1-V DNA
• Target Pathogen: Yersinia pestis
• Target Disease: Plague
• Vaccine Ontology ID: VO_0004314
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• Caf1 from Y. pestis biovar Microtus str. 91001 gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector pGT146-mIL-12 expressed the proplague epitope capsular antigen (F1-Ag) (Yamanaka et al., 2008).
  • Detailed Gene Information: Click Here.
• LcrV from Y. pestis biovar Microtus str. 91001 gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector pGT146-mIL-12 expressed the proplague epitope virulence antigen (V-Ag) (Yamanaka et al., 2008).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0005073
• Immunization Route: intranasal immunization

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Efficacy: Following pneumonic challenge, the best efficacy was obtained in mice primed with IL-12(Low)/F1-V vaccine with 80% survival compared to mice immunized with IL-12(Low)/F1, IL-12(Low)/V, or IL-12(Low) vector DNA vaccines (Yamanaka et al., 2008).