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Vaccine Detail
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Murine cytomegalovirus DNA vaccine pcDNA-89 encoding pp89 |
| Vaccine Information |
- Vaccine Name: Murine cytomegalovirus DNA vaccine pcDNA-89 encoding pp89
- Target Pathogen: Murine Cytomegalovirus
- Vaccine Ontology ID: VO_0004323
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- IE1
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pcDNAI/Amp expressed the murine cytomegalovirus (MCMV) immediate-early gene 1 (IE1) encodes an 89-kDa phosphoprotein (pp89) (González et al., 1996).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000130
- Immunization Route: Intradermal injection (i.d.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: In four separate trials, an average of 63% of the mice immunized with pcDNA-89 survived after lethal challenge, compared with 18% of the mice immunized with pcDNA (control) (González et al., 1996).
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| References |
González et al., 1996: González Armas JC, Morello CS, Cranmer LD, Spector DH. DNA immunization confers protection against murine cytomegalovirus infection. Journal of virology. 1996; 70(11); 7921-7928. [PubMed: 8892915].
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