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Vaccine Detail

Newcastle disease virus DNA vaccine pCAGF encoding the F protein
Vaccine Information
  • Vaccine Name: Newcastle disease virus DNA vaccine pCAGF encoding the F protein
  • Target Pathogen: Newcastle disease virus
  • Target Disease: Newcastle disease
  • Vaccine Ontology ID: VO_0004324
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Chicken
  • F fusion protein gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector Pcaggs expressed the Newcastle disease virus Fprotein (NDV-F) (Sakaguchi et al., 1996).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: Pcaggs DNA vaccine plasmid
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Chicken Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: At 9 weeks post-injection, chickens were challenged with the velogenic NDV Sato strain. The chickens that had the antibody against NDV-F from immunization were protected from lethal NDV challenge. The DNA vaccine conferred efficient protection against the disease (Sakaguchi et al., 1996).
References
Sakaguchi et al., 1996: Sakaguchi M, Nakamura H, Sonoda K, Hamada F, Hirai K. Protection of chickens from Newcastle disease by vaccination with a linear plasmid DNA expressing the F protein of Newcastle disease virus. Vaccine. 1996; 14(8); 747-752. [PubMed: 8817820].