• Vaccine Name: PRRSV DNA vaccine GST-ORF5 encoding GP5
• Target Pathogen: Porcine respiratory and reproductive syndrome virus
• Target Disease: Porcine Reproductive and Respiratory Syndrome (PRRS), Blue-Ear Pig Disease
• Vaccine Ontology ID: VO_0004325
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Pig, mouse
• GP5 protein gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector pET21a expressed the major envelope glycoprotein (GP5) of porcine reproductive and respiratory syndrome virus (PRRSV) (Pirzadeh and Dea, 1998).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000256
• Immunization Route: Intramuscular injection (i.m.)

Pig Response

• Vaccine Immune Response Type: VO_0000286
• Efficacy: Following a massive intratracheal challenge with the virulent IAF-Klop strain of PRRSV, DNA-vaccinated pigs were protected from generalized viraemia and the development of typical macroscopic lung lesions that were observed in unvaccinated, virus-challenged controls, as well as in pigs that were immunized with E. coli-expressed GST-ORF5 recombinant fusion protein (Pirzadeh and Dea, 1998).