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Vaccine Detail

PRRSV DNA vaccine GST-ORF5 encoding GP5
Vaccine Information
  • Vaccine Name: PRRSV DNA vaccine GST-ORF5 encoding GP5
  • Target Pathogen: Porcine respiratory and reproductive syndrome virus
  • Target Disease: Porcine Reproductive and Respiratory Syndrome (PRRS), Blue-Ear Pig Disease
  • Vaccine Ontology ID: VO_0004325
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Pig, mouse
  • GP5 protein gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pET21a expressed the major envelope glycoprotein (GP5) of porcine reproductive and respiratory syndrome virus (PRRSV) (Pirzadeh and Dea, 1998).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pET21a DNA vaccine plasmid
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Pig Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Following a massive intratracheal challenge with the virulent IAF-Klop strain of PRRSV, DNA-vaccinated pigs were protected from generalized viraemia and the development of typical macroscopic lung lesions that were observed in unvaccinated, virus-challenged controls, as well as in pigs that were immunized with E. coli-expressed GST-ORF5 recombinant fusion protein (Pirzadeh and Dea, 1998).
References
Pirzadeh and Dea, 1998: Pirzadeh B, Dea S. Immune response in pigs vaccinated with plasmid DNA encoding ORF5 of porcine reproductive and respiratory syndrome virus. The Journal of general virology. 1998; 79 ( Pt 5); 989-999. [PubMed: 9603313].