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Vaccine Detail
Rabies virus DNA vaccine pSG5rab.gp |
Vaccine Information |
- Vaccine Name: Rabies virus DNA vaccine pSG5rab.gp
- Target Pathogen: Rabies virus
- Target Disease: Rabies
- Vaccine Ontology ID: VO_0004326
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- glycoprotein
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pSG5 expressed the rabies glycoprotein (ERA strain) (Xiang et al., 1994).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000316
- Immunization Route: Intramuscular injection (i.m.)
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Host Response |
Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Immune Response: Mice immunized intramuscularly with the pSG5rab.gp vector developed rabies virus glycoprotein-specific cytolytic T cells, lymphokinesecreting T helper cells of the TH1 subset, and rabies virus-neutralizing antibodies (Xiang et al., 1994).
- Efficacy: Mice vaccinated with the pSG5rab.gp vector were fully protected against a subsequent challenge with rabies virus (Xiang et al., 1994).
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References |
Xiang et al., 1994: Xiang ZQ, Spitalnik S, Tran M, Wunner WH, Cheng J, Ertl HC. Vaccination with a plasmid vector carrying the rabies virus glycoprotein gene induces protective immunity against rabies virus. Virology. 1994; 199(1); 132-140. [PubMed: 8116236].
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