• Vaccine Name: Rabies virus DNA vaccine pSG5rab.gp
• Target Pathogen: Rabies virus
• Target Disease: Rabies
• Vaccine Ontology ID: VO_0004326
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• glycoprotein gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector pSG5 expressed the rabies glycoprotein (ERA strain) (Xiang et al., 1994).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000316
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Immune Response: Mice immunized intramuscularly with the pSG5rab.gp vector developed rabies virus glycoprotein-specific cytolytic T cells, lymphokinesecreting T helper cells of the TH1 subset, and rabies virus-neutralizing antibodies (Xiang et al., 1994).
• Efficacy: Mice vaccinated with the pSG5rab.gp vector were fully protected against a subsequent challenge with rabies virus (Xiang et al., 1994).