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Vaccine Detail
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Human papillomavirus DNA vaccine pC16-L1 encoding L1 |
| Vaccine Information |
- Vaccine Name: Human papillomavirus DNA vaccine pC16-L1 encoding L1
- Target Pathogen: Human Papillomavirus
- Target Disease: HPV infection
- Vaccine Ontology ID: VO_0004330
- Type: DNA vaccine
- Status: Research
- L1 HPV 16
gene engineering:
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000132
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Mice were challenged with a syngeneic melanoma cell line, engineered to express the HPV16-L1 protein, tumours in vaccinated animals showed slower growth rate, correlated directly with a longer survival of mice. The results suggest that the L1-based DNA vaccine may be useful for the prevention of primary infections by HPV16 (Rocha-Zavaleta et al., 2002).
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| References |
Rocha-Zavaleta et al., 2002: Rocha-Zavaleta L, Alejandre JE, Garcia-Carranca A. Parenteral and oral immunization with a plasmid DNA expressing the human papillomavirus 16-L1 gene induces systemic and mucosal antibodies and cytotoxic T lymphocyte responses. Journal of medical virology. 2002; 66(1); 86-95. [PubMed: 11748663].
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