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Vaccine Detail
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Human papillomavirus DNA vaccine E7SH DNA |
| Vaccine Information |
- Vaccine Name: Human papillomavirus DNA vaccine E7SH DNA
- Target Pathogen: Human Papillomavirus
- Target Disease: HPV infection
- Vaccine Ontology ID: VO_0004333
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- E7 Type 16
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pCDNA3 expressed the E7 oncogene of the human papillomavirus type 16 (HPV 16) (Osen et al., 2001).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000132
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Immunization of C57BL/6 mice with E7SH DNA induced E7-specific CTL and also conveyed protection against E7-positive syngeneic tumor cells. Mice were challenged with 2 doses of TC-1 cells 100 days apart, and there was no tumor growth in any of the mice up to 80 days post-rechallenge, showing that a single injection of E7SH DNA had induced a long-lasting protective immunity (Osen et al., 2001).
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| References |
Osen et al., 2001: Osen W, Peiler T, Ohlschläger P, Caldeira S, Faath S, Michel N, Müller M, Tommasino M, Jochmus I, Gissmann L. A DNA vaccine based on a shuffled E7 oncogene of the human papillomavirus type 16 (HPV 16) induces E7-specific cytotoxic T cells but lacks transforming activity. Vaccine. 2001; 19(30); 4276-4286. [PubMed: 11457555].
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