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Vaccine Detail
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VHSV DNA vaccine pCMV-vhsN encoding nucleocapsid protein N and glycoprotein G |
| Vaccine Information |
- Vaccine Name: VHSV DNA vaccine pCMV-vhsN encoding nucleocapsid protein N and glycoprotein G
- Target Pathogen: Viral haemorrhagic septicaemia virus
- Vaccine Ontology ID: VO_0004339
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Rainbow trout
- nucleocapsid
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pcDNA 3 expressed the gene encoding the nucleocapsid protein N (Heppel et al., 1997).
- Detailed Gene Information: Click Here.
- Glycoprotein
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pcDNA3 expressed glycoprotein G gene of the virus (Heppel et al., 1997).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000132
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Rainbow trout Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Young rainbow trout injected with the G construct together with the N construct were strongly protected against challenge with live virus (Heppel et al., 1997).
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| References |
Heppel et al., 1997: JOËL HEPPELL, NIELS LORENZEN, NEIL K. ARMSTRONG, TONG WU, ELLEN LORENZEN, KATJA EINER-JENSEN, JOACHIM SCHORR, HEATHER L. DAVIS. Development of DNA vaccines for fish: vector design, intramuscular injection and antigen expression using viral haemorrhagic septicaemia virus genes as model. Fish & Shellfish Immunology. 1997; 8(4); 271-286.
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