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Vaccine Detail

VHSV DNA vaccine pCMV-vhsN encoding nucleocapsid protein N and glycoprotein G
Vaccine Information
  • Vaccine Name: VHSV DNA vaccine pCMV-vhsN encoding nucleocapsid protein N and glycoprotein G
  • Target Pathogen: Viral haemorrhagic septicaemia virus
  • Vaccine Ontology ID: VO_0004339
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Rainbow trout
  • nucleocapsid gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pcDNA 3 expressed the gene encoding the nucleocapsid protein N (Heppel et al., 1997).
    • Detailed Gene Information: Click Here.
  • Glycoprotein gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pcDNA3 expressed glycoprotein G gene of the virus (Heppel et al., 1997).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pcDNA3 DNA vaccine plasmid
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Rainbow trout Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Young rainbow trout injected with the G construct together with the N construct were strongly protected against challenge with live virus (Heppel et al., 1997).
References
Heppel et al., 1997: JO√čL HEPPELL, NIELS LORENZEN, NEIL K. ARMSTRONG, TONG WU, ELLEN LORENZEN, KATJA EINER-JENSEN, JOACHIM SCHORR, HEATHER L. DAVIS. Development of DNA vaccines for fish: vector design, intramuscular injection and antigen expression using viral haemorrhagic septicaemia virus genes as model. Fish & Shellfish Immunology. 1997; 8(4); 271-286.