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Vaccine Detail
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SIV DNA vaccine pSIVgag and pmacIL-15 encoding SIV core protein |
| Vaccine Information |
- Vaccine Name: SIV DNA vaccine pSIVgag and pmacIL-15 encoding SIV core protein
- Target Pathogen: Simian Immunodeficiency Virus
- Target Disease: Simian AIDS
- Vaccine Ontology ID: VO_0004346
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Macaque
- Core protein
gene engineering:
- Type: DNA vaccine construction
- Description: This DNA vaccine expressed a 37-kDa fragment of the SIV core protein (Boyer et al., 2007).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0005066
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Macaque Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: The vaccine groups were protected from ongoing infection, and the IL-15 covaccinated group showed a more rapidly controlled infection than the group treated with DNA vaccine alone (Boyer et al., 2007).
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| References |
Boyer et al., 2007: Boyer JD, Robinson TM, Kutzler MA, Vansant G, Hokey DA, Kumar S, Parkinson R, Wu L, Sidhu MK, Pavlakis GN, Felber BK, Brown C, Silvera P, Lewis MG, Monforte J, Waldmann TA, Eldridge J, Weiner DB. Protection against simian/human immunodeficiency virus (SHIV) 89.6P in macaques after coimmunization with SHIV antigen and IL-15 plasmid. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(47); 18648-18653. [PubMed: 18000037].
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