• Vaccine Name: Hepatitis B DNA vaccine PLGA–CTAB–DNA encoding the small envelope gene
• Target Pathogen: Hepatitis B virus
• Target Disease: Hepatitis B
• Vaccine Ontology ID: VO_0004352
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• S gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector pVAX(S) expressed the small envelope gene of HBV (He et al., 2005).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000024
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Immune Response: PLGA–CTAB–DNA optimizes two key features during antigen presentation, controlled release and targeted delivery, which might be involved in the mechanisms of its augmented immunogenicity and enhanced immunoprotection (He et al., 2005)
• Challenge Protocol: Challenge with transplanted HBsAg-expressing tumor cells (He et al., 2005).
• Efficacy: Mice immunized with PLGA–CTAB–pVAX(S) (20 μg per mouse) or naked pVAX(S) (100 μg per mouse) after a challenge of transplanted HBsAg-expressing tumor cells showed weak protection efficacy, resulting in a final survival rate of 10% or 20% at week 15. However, mice immunized with PLGA–CTAB–pVAX(S) at the dose of 100 μg per mouse displayed a strong inhibition on tumor formation and a remarkable improvement in final survival rate (60%) (He et al., 2005).