• Vaccine Name: Duck hepatitis B DNA vaccine pcDNA I-S encoding small S proteins
• Target Pathogen: Hepatitis B virus
• Target Disease: Hepatitis B
• Vaccine Ontology ID: VO_0004353
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Duck
• Antigen: S protein from DHBV Australian strain (Triyatni et al., 1998)
• S gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000130
• Immunization Route: Intramuscular injection (i.m.)

Ducks Response

• Vaccine Immune Response Type: VO_0000286
• Immune Response: The S-DNA vaccine was able to elicit humoral immune responses against DHBV surface proteins in ducks. In addition, The S-DNA vaccine induced high titers of anti-DHBs antibodies, and anti-S antibodies induced by the S-DNA construct were highly effective in neutralizing virus infectivity. (Triyatni et al., 1998).
• Efficacy: Vaccination of ducks with S DNA vaccines prevented the development of viremia following virus challenge. All ducks were challenged with a high-titer dose of DHBV virus. Preincubation of the virus with 5, 10, or, 20 μl of anti-S serum at 37°C for 1 hour prior to i.v. inoculation into 1-day-old ducklings completely prevented the development of viremia during a 4-week observation period in all of the ducks (Triyatni et al., 1998).