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Vaccine Detail
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Hepatitis B DNA vaccine pCEA/HBsAg encoding CEA and HBsAg |
| Vaccine Information |
- Vaccine Name: Hepatitis B DNA vaccine pCEA/HBsAg encoding CEA and HBsAg
- Target Pathogen: Hepatitis B virus
- Target Disease: Hepatitis B
- Vaccine Ontology ID: VO_0004359
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Human
- HbS
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pcDNA3 expressed carcinoembryonic antigen (CEA) and hepatitis B surface antigen (HBsAg) (Conry et al., 2002).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000132
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Human Response
- Vaccine Immune Response Type: VO_0000286
- Immune Response: CEA-specific antibody and lymphoproliferative responses have been reported after vaccination with an anti-idiotype monoclonal antibody mimicking a portion of the CEA molecule in patients with colorectal carcinoma (Conry et al., 2002).
- Efficacy: Repetitive dosing of pCEA/HBsAg induced HBsAg antibodies in 6 of 8 patients, with protective antibody levels achieved in 4 of these patients. (Conry et al., 2002).
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| References |
Conry et al., 2002: Conry RM, Curiel DT, Strong TV, Moore SE, Allen KO, Barlow DL, Shaw DR, LoBuglio AF. Safety and immunogenicity of a DNA vaccine encoding carcinoembryonic antigen and hepatitis B surface antigen in colorectal carcinoma patients. Clinical cancer research : an official journal of the American Association for Cancer Research. 2002; 8(9); 2782-2787. [PubMed: 12231517].
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