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Vaccine Detail

M. tuberculosis DNA vaccine encoding Ag85B, MPT64 and MPT83
Vaccine Information
  • Vaccine Name: M. tuberculosis DNA vaccine encoding Ag85B, MPT64 and MPT83
  • Target Pathogen: Mycobacterium tuberculosis
  • Target Disease: Tuberculosis
  • Vaccine Ontology ID: VO_0004362
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • Ag85B from M. tuberculosis H37Rv gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pJW4303 expressed Ag85B of H37Rv (Cai et al., 2005).
    • Detailed Gene Information: Click Here.
  • MPT64 gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pJW4303 expressed MPT64 of H37Rv (Cai et al., 2005)
    • Detailed Gene Information: Click Here.
  • MPT83 gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pJW4303 expressed MPT83 of H37Rv (Cai et al., 2005).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pJW4303 DNA vaccine plasmid
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Combined DNA vaccines including Ag85B, MPT64, and MPT83 formulated in IL-2 provided an efficient method for generating strong and sustained protective immunity in the spleen and lungs of experimental mice following i.v. challenge with M. tuberculosis H37Rv (Cai et al., 2005).
  • Information about this animal model: Mouse Model for TB research
References
Cai et al., 2005: Cai H, Yu DH, Tian X, Zhu YX. Coadministration of interleukin 2 plasmid DNA with combined DNA vaccines significantly enhances the protective efficacy against Mycobacterium tuberculosis. DNA and cell biology. 2005; 24(10); 605-613. [PubMed: 16225391].