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Vaccine Detail

M. tuberculosis DNA vaccine (containing the ESAT-6, MPT-64, MPT-83, and KatG constructs)
Vaccine Information
  • Vaccine Name: M. tuberculosis DNA vaccine (containing the ESAT-6, MPT-64, MPT-83, and KatG constructs)
  • Target Pathogen: Mycobacterium tuberculosis
  • Target Disease: Tuberculosis
  • Vaccine Ontology ID: VO_0004363
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • MPT64 gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pJW4303 encoded MPT-64 (Morris et al., 2000).
    • Detailed Gene Information: Click Here.
  • MPT83 gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pJW4303 encoded MPT-83 (Morris et al., 2000).
    • Detailed Gene Information: Click Here.
  • KatG gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pJW4303 encoded KatG (Morris et al., 2000).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pJW4303 DNA vaccine plasmid
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: The relative protection in the lung induced by the combination vaccine approached the BCG response in these experiments (Morris et al., 2000).
  • Information about this animal model: Mouse Model for TB research
References
Morris et al., 2000: Morris S, Kelley C, Howard A, Li Z, Collins F. The immunogenicity of single and combination DNA vaccines against tuberculosis. Vaccine. 2000; 18(20); 2155-2163. [PubMed: 10715531].