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Vaccine Detail
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M. tuberculosis DNA vaccine DNAAg85A encoding a single immunogenic M.tb Ag |
| Vaccine Information |
- Vaccine Name: M. tuberculosis DNA vaccine DNAAg85A encoding a single immunogenic M.tb Ag
- Target Pathogen: Mycobacterium tuberculosis
- Target Disease: Tuberculosis
- Vaccine Ontology ID: VO_0004364
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- FbpA (Ag85A)
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pcDNA3.1 expressed a single immunogenic M.tb Ag (Ag85A) (Wang et al., 2004).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000158
- Immunization Route: intranasal immunization
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Systemic priming with two repeated DNAAg85A injections and respiratory mucosal boosting once with AdAg85A provided the most potent protection of all of the tested vaccines/regimens, including s.c. BCG vaccination both at 4 and 8 wk postchallenge, and this level of protection was also better than single i.n. AdAg85A vaccination at 8 wk postchallenge (Wang et al., 2004).
- Information about this animal model: Mouse Model for TB research
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| References |
Wang et al., 2004: Wang J, Thorson L, Stokes RW, Santosuosso M, Huygen K, Zganiacz A, Hitt M, Xing Z. Single mucosal, but not parenteral, immunization with recombinant adenoviral-based vaccine provides potent protection from pulmonary tuberculosis. Journal of immunology (Baltimore, Md. : 1950). 2004; 173(10); 6357-6365. [PubMed: 15528375].
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