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Vaccine Detail

Herpes simplex virus DNA vaccine ∆gB-2 encoding gB
Vaccine Information
  • Vaccine Name: Herpes simplex virus DNA vaccine ∆gB-2 encoding gB
  • Target Pathogen: Herpes simplex virus type 1 and 2
  • Target Disease: Herpes
  • Vaccine Ontology ID: VO_0004366
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse, guinea pig
  • UL27 gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector V1Jns expressed the hsV-2 gB gene (McClements et al., 1996).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid:
    • DNA vaccine plasmid name:
    • DNA vaccine plasmid VO ID: VO_0000328
  • Immunization Route: Intraperitoneal injection (i.p.)
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Immune Response: The DNA immunization has the capacity to elicit cell-mediated, as well as humoral immune responses. In addition, injection of mice showed that each construction induced neutralizing serum antibodies (McClements et al., 1996).
  • Efficacy: Immunized and control (saline-injected) mice were challenged by i.p. injection of HSV-2 and observed daily for survival. Significant protection from death was found for each dose tested (P< 0.01 for the 30, 10, and 3 ug groups, and P = 0.027 for the 1 ug group) (McClements et al., 1996).
References
McClements et al., 1996: McClements WL, Armstrong ME, Keys RD, Liu MA. Immunization with DNA vaccines encoding glycoprotein D or glycoprotein B, alone or in combination, induces protective immunity in animal models of herpes simplex virus-2 disease. Proceedings of the National Academy of Sciences of the United States of America. 1996; 93(21); 11414-11420. [PubMed: 8876149].