• Vaccine Name: Herpes simplex virus DNA vaccine ICP-27 DNA encoding ICP-27
• Target Pathogen: Herpes simplex virus type 1 and 2
• Target Disease: Herpes
• Vaccine Ontology ID: VO_0004367
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• ICP27 gene engineering:
  • Type: DNA vaccine construction
  • Description: This DNA vaccine expresses infectious cell polypeptide 27(ICP-27) (Manickan et al., 1997).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0005031
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Immune Response: DC-delivered DNA appeared to be associated mainly with an increased Thi CD4
  T cell response (Manickan et al., 1997).
• Efficacy: The majority of mice immunized with plasmid DNA encoding ICP 27 resisted challenge with 10 ID50 of virus (Manickan et al., 1997).