• Vaccine Name: Herpes simplex virus DNA vaccine encoding gD and gB from HSV-2 strain Curtis
• Target Pathogen: Herpes simplex virus type 1 and 2
• Target Disease: Herpes
• Vaccine Ontology ID: VO_0004370
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse, guinea pig
• Antigen: gD and gB from HSV-2 strain Curtis (McClements et al., 1997)
• gD gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector V1Jns expressed HSV envelope glycoproteins D (gD) (McClements et al., 1997).
  • Detailed Gene Information: Click Here.
• UL27 gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector V1Jns expressed HSV envelope glycoprotein B (UL27) (McClements et al., 1997).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0005044
• Immunization Route: Intramuscular injection (i.m.)

Guinea pig Response

• Vaccine Immune Response Type: VO_0000286
• Immune Response: Immunization with a plasmid expressing gB induced humoral immune responses and virus neutralization (McClements et al., 1997).
• Efficacy: When the gB plasmid was combined with a plasmid expressing full-length gD, immunized guinea pigs developed humoral responses to both proteins and were also significantly protected from viral challenge. In addition, immunized animals were partially protected from genital herpes, exhibiting significantly reduced primary and subsequent recurrent disease (McClements et al., 1997).