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Vaccine Detail

Rabies virus DNA vaccine pCMV-intA-rabies encoding glycoprotein G
Vaccine Information
  • Vaccine Name: Rabies virus DNA vaccine pCMV-intA-rabies encoding glycoprotein G
  • Target Pathogen: Rabies virus
  • Target Disease: Rabies
  • Vaccine Ontology ID: VO_0004371
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse, cat, dog
  • G gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pCMV-intA expressed the rabies glycoprotein G (Osorio et al., 1999).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pRc/RSV DNA vaccine plasmid
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Cat Response

  • Vaccine Immune Response Type: VO_0000286
  • Immune Response: Neutralizing antibody responses following DNA vaccination lasted at least nine months with high levels of RVNA in all i.m.-vaccinated dogs, and eleven of twelve i.d.-vaccinated cats. This suggests that a DNA rabies vaccine can induce durable and protective immune responses against rabies infection in companion animals (Osorio et al., 1999).
  • Efficacy: The geometric mean RVNA titer in the combined intradermal cat groups at day 289 was 341, a titer that correlates with solid protection against rabies challenge. Thus, it is reasonable to conclude that the high neutralization activity observed in the studies described here will afford protection against challenge, even though a challenge study was not performed (Osorio et al., 1999).
References
Osorio et al., 1999: Osorio JE, Tomlinson CC, Frank RS, Haanes EJ, Rushlow K, Haynes JR, Stinchcomb DT. Immunization of dogs and cats with a DNA vaccine against rabies virus. Vaccine. 1999; 17(9-10); 1109-1116. [PubMed: 10195621].