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Vaccine Detail
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T. cruzi DNA vaccine encoding ASP-2 |
| Vaccine Information |
- Vaccine Name: T. cruzi DNA vaccine encoding ASP-2
- Target Pathogen: Trypanosoma cruzi
- Target Disease: Chagas disease
- Vaccine Ontology ID: VO_0004375
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- amastigote surface protein-2
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pGEX-3X expressed amastigote surface protein 2 (ASP-2 ) (Araújo et al., 2005).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000259
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Immune Response: Vaccination with a plasmid expressing amastigote surface protein 2 (ASP-2) generates specific CD4+ Th1 and CD8+ Tc1 immune responses (Araújo et al., 2005).
- Efficacy: DNA vaccination with the gene encoding amastigote surface protein 2 (ASP-2) protects approximately 65% of highly susceptible A/Sn mice against the lethal Trypanosoma cruzi infection (Araújo et al., 2005).
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| References |
Araújo et al., 2005: Araújo AF, de Alencar BC, Vasconcelos JR, Hiyane MI, Marinho CR, Penido ML, Boscardin SB, Hoft DF, Gazzinelli RT, Rodrigues MM. CD8+-T-cell-dependent control of Trypanosoma cruzi infection in a highly susceptible mouse strain after immunization with recombinant proteins based on amastigote surface protein 2. Infection and immunity. 2005; 73(9); 6017-6025. [PubMed: 16113322].
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