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Vaccine Detail
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Ebola virus recombinant vector vaccine pVSVXN2∆G/ZEBOVsGP encoding GP |
| Vaccine Information |
- Vaccine Name: Ebola virus recombinant vector vaccine pVSVXN2∆G/ZEBOVsGP encoding GP
- Target Pathogen: Ebola virus
- Target Disease: Ebola hemorrhagic fever
- Vaccine Ontology ID: VO_0004381
- Type: Recombinant vector vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- GP from Zaire ebolavirus
gene engineering:
- Type: Recombinant vector construction
- Description: Vector VSVXN2∆G expressed the transmembrane glycoproteins of Zaire Ebola virus (GP) (Garbutt et al., 2004).
- Detailed Gene Information: Click Here.
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: The rVSV expressing the Zaire Ebola virus transmembrane glycoprotein mediated protection in mice against a lethal Zaire Ebola virus challenge (Garbutt et al., 2004).
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| References |
Garbutt et al., 2004: Garbutt M, Liebscher R, Wahl-Jensen V, Jones S, Möller P, Wagner R, Volchkov V, Klenk HD, Feldmann H, Ströher U. Properties of replication-competent vesicular stomatitis virus vectors expressing glycoproteins of filoviruses and arenaviruses. Journal of virology. 2004; 78(10); 5458-5465. [PubMed: 15113924].
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