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Vaccine Detail

Ebola virus recombinant vector vaccine Ad-CMVZGP encoding the glycoprotein
Vaccine Information
  • Vaccine Name: Ebola virus recombinant vector vaccine Ad-CMVZGP encoding the glycoprotein
  • Target Pathogen: Ebola virus
  • Target Disease: Ebola hemorrhagic fever
  • Vaccine Ontology ID: VO_0004383
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • GP from Zaire ebolavirus gene engineering:
    • Type: Recombinant vector construction
    • Description: Vector Human adenovirus serotype 5 (Ad) expressed the Zaire ebolavirus (ZEBOV) envelope glycoprotein (Richardson et al., 2009).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Immune Response: Vaccination following viral challenge produced enhanced T and B cell immune responses with a low dose of Ad-CAGoptZGP. The frequency of IFN-γ+CD8 T cells with Ad-CMVZGP at 1×10^7 IFU/mouse was at 1.6±0.4%, on average (Richardson et al., 2009).
  • Efficacy: Protection following Zaire ebola virus challenge was complete in mice vaccinated with Ad-CMVZGP at 1×10^6 and 1×10^7 IFU/mouse but was only partially protective at 1×10^5 IFU/mouse (Richardson et al., 2009).
References
Richardson et al., 2009: Richardson JS, Yao MK, Tran KN, Croyle MA, Strong JE, Feldmann H, Kobinger GP. Enhanced protection against Ebola virus mediated by an improved adenovirus-based vaccine. PloS one. 2009; 4(4); e5308. [PubMed: 19390586].