• Vaccine Name: Ebola virus recombinant vector vaccine Ad-CAGoptZGP encoding the envelope glycoprotein
• Target Pathogen: Ebola virus
• Target Disease: Ebola hemorrhagic fever
• Vaccine Ontology ID: VO_0004384
• Type: Recombinant vector vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse, guinea pig
• GP from Zaire ebolavirus gene engineering:
  • Type: Recombinant vector construction
  • Description: Vector Human adenovirus serotype 5 (Ad) expressed the Zaire ebolavirus (ZEBOV) envelope glycoprotein (Richardson et al., 2009).
  • Detailed Gene Information: Click Here.
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Immune Response: Ad-CAGoptZGP at a dose of 1×10^5 IFU/mouse elicited a frequency of 1.3±0.3% positive IFN-γ producing CD8+ T cells. Overall, the average frequency of positive IFN-γ producing CD8+ T cells was slightly higher with a lower dose of Ad-CAGoptZGP than with a higher dose of Ad-CMVZGP (Richardson et al., 2009).
• Efficacy: All mice vaccinated with doses of 1×10^4, 1×10^5 and 1×10^6 IFU/mouse of Ad-CAGoptZGP were fully protected from the viral challenge with no weight loss or other clinical signs of disease (Richardson et al., 2009).