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Vaccine Detail

B. anthracis DNA vaccine PA
Vaccine Information
  • Vaccine Name: B. anthracis DNA vaccine PA
  • Target Pathogen: Bacillus anthracis
  • Target Disease: Anthrax
  • Vaccine Ontology ID: VO_0004386
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Rabbit, guinea pig, mouse
  • pagA gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pWRG7079 expressed protective (PA) gene of B. anthracis (Riemenschneider et al., 2003).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pWRG7079 DNA vaccine plasmid
  • Immunization Route: Gene gun
Host Response

Rabbit Response

  • Vaccine Immune Response Type: VO_0000286
  • Immune Response: All rabbits vaccinated with the DNA vaccine or with AVA vaccine developed antibody responses predictive of protective immunity to anthrax challenge (Riemenschneider et al., 2003).
  • Efficacy: Evaluating antibody responses by ELISA and TNA revealed that all rabbits vaccinated with the DNA vaccine developed antibody responses predictive of protective immunity to anthrax challenge. After a fourth vaccination, titers rebounded and the rabbits were challenged by subcutaneous injection of 100 LD50 of B. anthracis Ames strain heat-shocked spores - 9/10 rabbits given the PA DNA vaccine survived (Riemenschneider et al., 2003).
References
Riemenschneider et al., 2003: Riemenschneider J, Garrison A, Geisbert J, Jahrling P, Hevey M, Negley D, Schmaljohn A, Lee J, Hart MK, Vanderzanden L, Custer D, Bray M, Ruff A, Ivins B, Bassett A, Rossi C, Schmaljohn C. Comparison of individual and combination DNA vaccines for B. anthracis, Ebola virus, Marburg virus and Venezuelan equine encephalitis virus. Vaccine. 2003; 21(25-26); 4071-4080. [PubMed: 12922144].