• Vaccine Name: B. anthracis DNA vaccine PA
• Target Pathogen: Bacillus anthracis
• Target Disease: Anthrax
• Vaccine Ontology ID: VO_0004386
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Rabbit, guinea pig, mouse
• pagA gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector pWRG7079 expressed protective (PA) gene of B. anthracis (Riemenschneider et al., 2003).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0005059
• Immunization Route: Gene gun

Rabbit Response

• Vaccine Immune Response Type: VO_0000286
• Immune Response: All rabbits vaccinated with the DNA vaccine or with AVA vaccine developed antibody responses predictive of protective immunity to anthrax challenge (Riemenschneider et al., 2003).
• Efficacy: Evaluating antibody responses by ELISA and TNA revealed that all rabbits vaccinated with the DNA vaccine developed antibody responses predictive of protective immunity to anthrax challenge. After a fourth vaccination, titers rebounded and the rabbits were challenged by subcutaneous injection of 100 LD50 of B. anthracis Ames strain heat-shocked spores - 9/10 rabbits given the PA DNA vaccine survived (Riemenschneider et al., 2003).