• Vaccine Name: Marburg virus DNA vaccine DNA-GP encoding GP
• Target Pathogen: Marburg Virus
• Target Disease: Hemorrhagic fever
• Vaccine Ontology ID: VO_0004390
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Macaque
• GP from Musoke Marburgvirus gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector CMV/R expressed GP of MARV (Geisbert et al., 2010).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0005004
• Immunization Route: Intramuscular injection (i.m.)

Macaque Response

• Vaccine Immune Response Type: VO_0000286
• Immune Response: The DNA/DNA vaccine induced humoral responses comparable to those induced by a single inoculation with rAd5-GP, as well as CD4(+) and CD8(+) cellular immune responses, with skewing toward CD4(+) T-cell activity against MARV GP (Geisbert et al., 2010).
• Efficacy: The DNA-GP-only vaccine prevented death in all vaccinated subjects after challenge with a lethal dose of MARV Angola (Geisbert et al., 2010).