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Vaccine Detail
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Marburg virus recombinant vector vaccine MBGV GP |
| Vaccine Information |
- Vaccine Name: Marburg virus recombinant vector vaccine MBGV GP
- Target Pathogen: Marburg Virus
- Target Disease: Hemorrhagic fever
- Vaccine Ontology ID: VO_0004391
- Type: Recombinant vector vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Guinea pig, macaques
- GP from Musoke Marburgvirus
gene engineering:
- Type: Recombinant vector construction
- Description: Vector Venezuelan equine encephalitis (VEE) virus expressed the gene for MBGV GP (Hevey et al., 1998).
- Detailed Gene Information: Click Here.
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Macaque Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Three monkeys vaccinated with replicons which expressed MBGV GP, and three others vaccinated with both replicons that expressed GP or NP, remained aviremic and were completely protected from disease (Hevey et al., 1998).
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| References |
Hevey et al., 1998: Hevey M, Negley D, Pushko P, Smith J, Schmaljohn A. Marburg virus vaccines based upon alphavirus replicons protect guinea pigs and nonhuman primates. Virology. 1998 Nov 10; 251(1); 28-37. [PubMed: 9813200 ].
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