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Vaccine Detail
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B. abortus DNA vaccine pcDNA3-SOD encoding Cu-Zn SOD |
| Vaccine Information |
- Vaccine Name: B. abortus DNA vaccine pcDNA3-SOD encoding Cu-Zn SOD
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0004393
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- SodC from B. abortus strain 2308
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pcDNA3 expressed Cu-Zn SOD (Onate et al., 2003).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000132
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Immune Response: Vaccination was able to induce a broad range of immune responses including antibody production, CD8+ cytotoxic T cells (CTLs), and CD4+ T helper cell activation (Onate et al., 2003).
- Efficacy: Immunization with pcDNA-SOD resulted in a significantly higher degree of protection (2.16 log increase in protection) compared to the unimmunized control groups (P < 0.0005). The level of protection was similar to the one induced by B. abortus vaccine strain RB51. Thus, pcDNA-SOD vaccine afforded a significant degree of protection against Brucella infection (Onate et al., 2003).
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| References |
Onate et al., 2003: Onate AA, Cespedes S, Cabrera A, Rivers R, Gonzalez A, Munoz C, Folch H, Andrews E. A DNA vaccine encoding Cu,Zn superoxide dismutase of Brucella abortus induces protective immunity in BALB/c mice. Infection and immunity. 2003 Sep; 71(9); 4857-61. [PubMed: 12933826].
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