VIOLIN Logo
VO Banner
Search: for Help
About
Introduction
Statistics
VIOLIN News
Your VIOLIN
Register or Login
Submission
Tutorial
Vaccine & Components
Vaxquery
Vaxgen
VBLAST
Protegen
VirmugenDB
DNAVaxDB
CanVaxKB
Vaxjo
Vaxvec
Vevax
Huvax
Cov19VaxKB
Vaccine Mechanisms
VaximmutorDB
Vaxism
Vaxar
Vaccine Literature
VO-SciMiner
Litesearch
Vaxmesh
Vaxlert
Vaccine Design
Vaxign2
Vaxign
Community Efforts
Vaccine Ontology
ICoVax 2012
ICoVax 2013
Advisory Committee
Vaccine Society
Vaxperts
VaxPub
VaxCom
VaxLaw
VaxMedia
VaxMeet
VaxFund
VaxCareer
Data Exchange
V-Utilities
VIOLINML
Help & Documents
Publications
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

Vaccine Detail

Adjuvant arthritis DNA vaccine CII encoding type II collagen
Vaccine Information
  • Vaccine Name: Adjuvant arthritis DNA vaccine CII encoding type II collagen
  • Target Pathogen: Arthritis
  • Vaccine Ontology ID: VO_0004409
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • Collagen type II gene engineering:
    • Type: DNA vaccine construction
    • Description:
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pTARGET DNA vaccine plasmid
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Immune Response: In vitro analysis of anti-CII T cells demonstrated reduced production of the pro-inflammatory cytokines IFN-γ and TNF-α in CII vaccinated mice. Further, CII DNA vaccines reduced epitope spreading of auto-reactive B cell responses in CIA (Ho et al., 2006).
  • Efficacy: DNA encoding CII reduced the disease severity and disease incidence of collagen-induced arthritis to 50% as compared to the PBS-treated control group in which the disease was more severe and the disease incidence was 89% (Ho et al., 2006).
  • Host Ifng (Interferon gamma) response
    • Description: CII-stimulated lymphocytes isolated from CIA mice treated with a DNA vaccine encoding CII produced significantly less IFN-g and TNF-a compared to PBS and DNA vector-IL-4 treated mice (Ho et al., 2006).
    • Detailed Gene Information: Click Here.
  • Host TNF-alpha response
    • Description: CII-stimulated lymphocytes isolated from CIA mice treated with a DNA vaccine encoding CII produced significantly less IFN-g and TNF-a compared to PBS and DNA vector-IL-4 treated mice (Ho et al., 2006).
    • Detailed Gene Information: Click Here.
References
Ho et al., 2006: Ho PP, Higgins JP, Kidd BA, Tomooka B, Digennaro C, Lee LY, de Vegvar HE, Steinman L, Robinson WH. Tolerizing DNA vaccines for autoimmune arthritis. Autoimmunity. 2006; 39(8); 675-682. [PubMed: 17178564].