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Vaccine Detail

Herpes simplex virus DNA vaccine pCI-gB encoding gB
Vaccine Information
  • Vaccine Name: Herpes simplex virus DNA vaccine pCI-gB encoding gB
  • Target Pathogen: Herpes simplex virus type 1 and 2
  • Target Disease: Herpes
  • Vaccine Ontology ID: VO_0004412
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • gB gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pCI expressed glycoprotein B of herpes simplex virus type 1 (Hariharan et al., 1998).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid:
    • DNA vaccine plasmid name:
    • DNA vaccine plasmid VO ID: VO_0000212
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Immune Response: A single intramuscular immunization of BALB/c mice with pSIN vectors expressing the glycoprotein B of herpes simplex virus type 1 induced a broad spectrum of immune responses, including virus-specific antibodies, cytotoxic T cells, and protection from lethal virus challenge in two different murine models (Hariharan et al., 1998).
  • Efficacy: 100% of the mice surviving the lethal i.p. McKrae challenge, demonstrating complete protection. None of the mice immunized with 100-μg doses of either negative control plasmid (pCI-HBVe or pSIN1.5-HBVe) survived (Hariharan et al., 1998).
References
Hariharan et al., 1998: Hariharan MJ, Driver DA, Townsend K, Brumm D, Polo JM, Belli BA, Catton DJ, Hsu D, Mittelstaedt D, McCormack JE, Karavodin L, Dubensky TW Jr, Chang SM, Banks TA. DNA immunization against herpes simplex virus: enhanced efficacy using a Sindbis virus-based vector. Journal of virology. 1998; 72(2); 950-958. [PubMed: 9444987].