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Vaccine Detail

B. burgdorferi DNA vaccine pCMV-ZS7/TPA encoding OspC from Borrelia burgdorferi sensu lato
Vaccine Information
  • Vaccine Name: B. burgdorferi DNA vaccine pCMV-ZS7/TPA encoding OspC from Borrelia burgdorferi sensu lato
  • Target Pathogen: Borrelia burgdorferi
  • Target Disease: Lyme Disease
  • Vaccine Ontology ID: VO_0004413
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • OspC gene engineering:
    • Type: DNA vaccine construction
    • Description:
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pCMV-TPA/ZS7 DNA vaccine plasmid
  • Immunization Route: Intradermal injection (i.d.)
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Immune Response: Both i.d. injection and gene-gun application of plasmid DNA encoding the ospC gene induced a reliable humoral response with high antibody titers, antigen-specific cellular responses and, most importantly, provided effective protection (Scheiblhofer et al., 2003).
  • Challenge Protocol: Control groups received challenge doses B. burgdorferi strain ZS7 of 104, 103, 102, and 10 live spirochetes per animal (Scheiblhofer et al., 2003).
  • Efficacy: The protection rate after challenge with 10 B. burgdorferi organisms per mouse was between 80% and 100% for all groups. These results demonstrate that a DNA vaccine encoding OspC of B. burgdorferi is suitable for inducing protection against Lyme borreliosis (Scheiblhofer et al., 2003).
References