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Vaccine Detail
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B. anthracis DNA vaccine pDNA encoding PA |
| Vaccine Information |
- Vaccine Name: B. anthracis DNA vaccine pDNA encoding PA
- Target Pathogen: Bacillus anthracis
- Target Disease: Anthrax
- Vaccine Ontology ID: VO_0004416
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Rabbit
- PA83
gene engineering:
- Type: DNA vaccine construction
- Description: This DNA vaccine expressed the protective antigen (PA) (Hermanson et al., 2004).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000334
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Rabbit Response
- Vaccine Immune Response Type: VO_0000286
- Immune Response: High titers of anti-PA and neutralizing antibody to lethal toxin (Letx) were achieved in all rabbits (Hermanson et al., 2004).
- Efficacy: Eight or nine animals in each group were challenged with 100x LD(50) of aerosolized anthrax spores 5 or 9 weeks after vaccination. An additional 10 animals vaccinated with PA pDNA were challenged >7 months postvaccination. All animals receiving PA pDNA vaccines were protected (Hermanson et al., 2004).
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| References |
Hermanson et al., 2004: Hermanson G, Whitlow V, Parker S, Tonsky K, Rusalov D, Ferrari M, Lalor P, Komai M, Mere R, Bell M, Brenneman K, Mateczun A, Evans T, Kaslow D, Galloway D, Hobart P. A cationic lipid-formulated plasmid DNA vaccine confers sustained antibody-mediated protection against aerosolized anthrax spores. Proceedings of the National Academy of Sciences of the United States of America. 2004 Sep 14; 101(37); 13601-6. [PubMed: 15342913].
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