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Vaccine Detail

B. anthracis DNA vaccine LF pDNA encoding LF
Vaccine Information
  • Vaccine Name: B. anthracis DNA vaccine LF pDNA encoding LF
  • Target Pathogen: Bacillus anthracis
  • Target Disease: Anthrax
  • Vaccine Ontology ID: VO_0004417
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Rabbit
  • Lef gene engineering:
    • Type: DNA vaccine construction
    • Description: This DNA vaccine expressed lethal factor (LF) (Hermanson et al., 2004).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pVR1012 DNA vaccine plasmid
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Rabbit Response

  • Vaccine Immune Response Type: VO_0000286
  • Immune Response: High titers of anti-LF and neutralizing antibody to lethal toxin (Letx) were achieved in all rabbits (Hermanson et al., 2004).
  • Efficacy: Eight or nine animals in each group were challenged with 100x LD(50) of aerosolized anthrax spores 5 or 9 weeks after vaccination and 5 of 9 animals receiving LF pDNA survived. In addition, the time to death was significantly delayed in the others (Hermanson et al., 2004).
References
Hermanson et al., 2004: Hermanson G, Whitlow V, Parker S, Tonsky K, Rusalov D, Ferrari M, Lalor P, Komai M, Mere R, Bell M, Brenneman K, Mateczun A, Evans T, Kaslow D, Galloway D, Hobart P. A cationic lipid-formulated plasmid DNA vaccine confers sustained antibody-mediated protection against aerosolized anthrax spores. Proceedings of the National Academy of Sciences of the United States of America. 2004 Sep 14; 101(37); 13601-6. [PubMed: 15342913].