• Vaccine Name: Cancer DNA vaccine p.DOM-AH1 encoding fragment C
• Target Pathogen: Cancer
• Target Disease: Cancer
• Vaccine Ontology ID: VO_0004425
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• Fragment C from tetanus toxin gene engineering:
  • Type: DNA vaccine construction
  • Description: This DNA vaccine expressed the first domain of fragment C (FrC)3 from tetanus toxin (DOM; TT865–1120) with sequence encoding the AH1 CTL epitope fused to the 3 terminus (Buchan et al., 2005).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000132
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Immune Response: Vaccination was rendered effective by electroporation, priming higher levels of AH1-specific CD8(+) T cells able to protect mice from tumor growth (Buchan et al., 2005).
• Efficacy: Delivery in a suboptimal volume (2 × 10 μl) did not mediate protection. However, protective efficacy was completely restored when suboptimal volume was combined with electroporation (p < 0.003). Therefore, this vaccine was able to protect from CT26 tumor in vivo (Buchan et al., 2005).