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Vaccine Detail
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Lung metastasis DNA vaccine pCEP4-MUC1 encoding MUC1 |
| Vaccine Information |
- Vaccine Name: Lung metastasis DNA vaccine pCEP4-MUC1 encoding MUC1
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0004437
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- MUC1
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pCEP4 expressed MUC1, a transmembrane molecule whose major extracellular domain is composed of tandem repeat units of 20 amino acids (Kamata et al., 2002).
- Detailed Gene Information: Click Here.
- Muc1
gene engineering:
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000175
- Immunization Route: Intradermal injection (i.d.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: The number of lung metastatic nodules three weeks after inoculation of F10-MUC1-C8 cells was significantly lower in mice immunized with pCEP4-MUC1 DNA vaccine 3 times at weekly intervals than in mice immunized with the vector DNA alone or with a single immunization of the DNA vaccine (Kamata et al., 2002).
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| References |
Kamata et al., 2002: Kamata M, Denda-Nagai K, Kubota N, Aida S, Takeda K, Irimura T. Vaccination of mice with MUC1 cDNA suppresses the development of lung metastases. Clinical & experimental metastasis. 2002; 19(8); 689-696. [PubMed: 12553374].
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