|
|
Vaccine Detail
|
Melanoma DNA vaccine gp75 DNA encoding melanosomal membrane glycoproteins, gp75 |
| Vaccine Information |
- Vaccine Name: Melanoma DNA vaccine gp75 DNA encoding melanosomal membrane glycoproteins, gp75
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0004440
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- HUMGP 75
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- TRP-2
gene engineering:
- Type: Recombinant protein preparation
- Description: This article informs the gene used in the cancer vaccine engineering. (Weber et al., 1998)
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0005013
- Immunization Route: Gene gun
|
| Host Response |
|
Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Mice immunized with hgp75 were significantly protected from lung metastases compared with control mice (mice immunized with a null vector). There was an 86% decrease in lung nodules (Weber et al., 1998).
|
| References |
Weber et al., 1998: Weber LW, Bowne WB, Wolchok JD, Srinivasan R, Qin J, Moroi Y, Clynes R, Song P, Lewis JJ, Houghton AN. Tumor immunity and autoimmunity induced by immunization with homologous DNA. The Journal of clinical investigation. 1998; 102(6); 1258-1264. [PubMed: 9739060].
|
|
