• Vaccine Name: Prostate cancer DNA vaccine pcDNA3-STEAP encoding six-transmembrane epithelial antigen
• Target Pathogen: Cancer
• Target Disease: Cancer
• Vaccine Ontology ID: VO_0004445
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• Steap1 gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector pcDNA3 expressed six-transmembrane epithelial antigen of the prostate (Garcia-Hernandez et al., 2007).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000132
• Immunization Route: subcutaneous injection

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Efficacy: Survival was significantly prolonged in mice vaccinated with mSTEAP using DNA, VRP (Venezuelan equine encephalitis virus-like replicon particles), or a combined strategy after tumor challenge compared with control mice. Although all STEAP-based vaccination strategies significantly slowed tumor growth in tumor-challenged mice, DNA vaccination followed by boosting with VRP was the most effective way of inducing protective immunity (Garcia-Hernandez et al., 2007).