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Vaccine Detail
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Prostate cancer DNA vaccine hPSMAt encoding PSMA |
| Vaccine Information |
- Vaccine Name: Prostate cancer DNA vaccine hPSMAt encoding PSMA
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0004446
- Type: DNA vaccine
- Status: Research
- Prostate-specific membrane antigen
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pVAX1 expressed human prostate-specific membrane antigen, PSMA (Mincheff et al., 2006).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000024
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Rat Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Only two of the 10 animals immunized against human PSMA developed tumors. In contrast, 17 of the 20 animals in the control groups developed tumors. The tumors, developing in the group, immunized with the human construct, were smaller than the ones in the control group (Mincheff et al., 2006).
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| References |
Mincheff et al., 2006: Mincheff M, Zoubak S, Makogonenko Y. Immune responses against PSMA after gene-based vaccination for immunotherapy-A: results from immunizations in animals. Cancer gene therapy. 2006; 13(4); 436-444. [PubMed: 16276349].
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