VIOLIN Logo
VO Banner
Search: for Help
About
Introduction
Statistics
VIOLIN News
Your VIOLIN
Register or Login
Submission
Tutorial
Vaccine & Components
Vaxquery
Vaxgen
VBLAST
Protegen
VirmugenDB
DNAVaxDB
CanVaxKB
Vaxjo
Vaxvec
Vevax
Huvax
Vaccine Mechanisms
Vaximmutordb
Vaxism
Vaxar
Vaccine Literature
VO-SciMiner
Litesearch
Vaxmesh
Vaxlert
Vaccine Design
Vaxign
Community Efforts
Vaccine Ontology
ICoVax 2012
ICoVax 2013
Advisory Committee
Vaccine Society
Vaxperts
VaxPub
VaxCom
VaxLaw
VaxMedia
VaxMeet
VaxFund
VaxCareer
Data Exchange
V-Utilities
VIOLINML
Help & Documents
Publications
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

Vaccine Detail

Prostate cancer DNA vaccine PSCA-HSP encoding PSCA and HSP
Vaccine Information
  • Vaccine Name: Prostate cancer DNA vaccine PSCA-HSP encoding PSCA and HSP
  • Target Pathogen: Cancer
  • Target Disease: Cancer
  • Vaccine Ontology ID: VO_0004450
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • HSP47 gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pcDNA3.1(+) expressed heat shock proteins (Zhang et al., 2007).
    • Detailed Gene Information: Click Here.
  • Prostate stem cell antigen gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pcDNA3.1(+) expressed prostate stem cell antigen (PSCA) (Zhang et al., 2007).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pcDNA3.1 DNA vaccine plasmid
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: The growth of RM-PSCA tumors was significantly slower in the groups vaccinated with PSCA-HSP, HSP-PSCA, and PSCA + HSP plasmids compared with that in the groups treated with PBS or pcDNA-HSP (P < 0.05). Furthermore, the survival time of mice vaccinated with PSCA-HSP (range 40–69 days) was significantly longer as compared with that of groups injected with HSP-PSCA and PSCA + HSP plasmids (P = 0.016 and P = 0.015, respectively) (Zhang et al., 2007).
References
Zhang et al., 2007: Zhang X, Yu C, Zhao J, Fu L, Yi S, Liu S, Yu T, Chen W. Vaccination with a DNA vaccine based on human PSCA and HSP70 adjuvant enhances the antigen-specific CD8+ T-cell response and inhibits the PSCA+ tumors growth in mice. The journal of gene medicine. 2007; 9(8); 715-726. [PubMed: 17595048].