• Vaccine Name: Prostate cancer DNA vaccine pmPSCA encoding PSCA
• Target Pathogen: Cancer
• Target Disease: Cancer
• Vaccine Ontology ID: VO_0004452
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• Prostate stem cell antigen gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector pIRES2 DsRed2 expressed murine prostate stem cell antigen (PSCA) (Ahmad et al., 2009).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000272
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Efficacy: These experiments demonstrated 37% relative risk reduction of tumor development in the pmPSCA group, but importantly vaccinated tumor bearing mice also had significantly less tumor burden than the control groups. Tumor growth kinetics indicated slower tumor growth in the pmPSCA treated group (versus empty vector P = 0.04, versus untreated P = 0.01). These results demonstrated that the pmPSCA could provide either complete protection or result in containment of the disease (Ahmad et al., 2009).