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Vaccine Detail

T. gondii DNA vaccine pMIC3i encoding the complete MIC3-ORF (RH(ERP) strain)
Vaccine Information
  • Vaccine Name: T. gondii DNA vaccine pMIC3i encoding the complete MIC3-ORF (RH(ERP) strain)
  • Target Pathogen: Toxoplasma gondii
  • Target Disease: Toxoplasmosis
  • Vaccine Ontology ID: VO_0004453
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • MIC3 gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pcDNA3 expressed MIC3 (Ismael et al., 2009).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pcDNA3 DNA vaccine plasmid
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Mice immunized with pMIC3i displayed significant protection against an oral challenge with 76K T. gondii strain cysts, exhibiting fewer brain cysts than the control mice immunized with the empty plasmid pcDNA3. The co-administration of pGM-CSF enhanced this protection (Ismael et al., 2009).
References
Ismael et al., 2009: Ismael AB, Hedhli D, Cérède O, Lebrun M, Dimier-Poisson I, Mévélec MN. Further analysis of protection induced by the MIC3 DNA vaccine against T. gondii: CD4 and CD8 T cells are the major effectors of the MIC3 DNA vaccine-induced protection, both Lectin-like and EGF-like domains of MIC3 conferred protection. Vaccine. 2009; 27(22); 2959-2966. [PubMed: 19428907].